Karnatak University Journal of Science

Volume: 55 Issue: 3

  • Open Access
  • Original Article

Synthesis of Novel Quinazolines and its Application as Biomarkers for Apoptotic Cells

Atulkumar A Kamble1, Barnabas Kodasi2, Sandhya Kumari3, Guruprasad Kalthur3, Praveen K Bayannavar2, Ravindra R Kamble1,∗

 
 

1Department of Chemistry, K. L. E. Society’s G. I. Bagewadi’s Arts Science and Commerce College, Nipani, 591237, Karnataka, India.
2Department of Studies in Chemistry, Karnataka University, Dharwad, 580003, Karnataka, India.
3Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. 


∗ Corresponding author email: [email protected]

 
 

Year: 2024, Page: 22-28, Doi: https://doi.org/10.61649/kujos/v55i3.24.3

Received: Feb. 7, 2024 Accepted: May 3, 2024 Published: Aug. 12, 2024

Abstract

The current study provides a straightforward, simple, and efficient protocol for the microwave- assisted synthesis of a series of 2,3-dihydroquinazolinones and its affinity to bind to DNA so as to exhibit potential anticancer activity. The predominance of this method is smooth synthetic pathway, transient reaction times, facile workup, and exceptional yields. Docking studies manifested strong binding interactions with BSA enzyme (PDB ID: 3V03). The compound 6d was exceptional in binding to DNA. Compound 6d showed significant cytotoxicity and genotoxicity against Ehrlich Ascites Carcinoma (EAC) cells. UV–Vis absorption and Fluorescence studies were carried out for compound 6d showing promising results.

 
 

Keywords: 2,3-dihydroquinazolinones; Cytotoxicity; Genotoxicity; UV–Vis absorption studies; Fluorescence studies

 

 
 

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Cite this article

Atulkumar A Kamble, Barnabas Kodasi, Sandhya Kumari, Guruprasad Kalthur, Praveen K Bayannavar, Ravindra R Kamble. Synthesis of Novel Quinazolines and its Application as Biomarkers for Apoptotic Cells. Karnatak University Journal of Science 55(3), (2024), 22–28

 
 
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