Volume: 55 Issue: 1
Year: 2024, Page: 1-16, Doi: https://doi.org/10.61649/kujos/v55i1.23.10
Received: Oct. 18, 2023 Accepted: March 27, 2024 Published: March 29, 2024
Due to the ever increasing population, rapid industrialization and urbanization, the toxic effects of heavy metals has become a major concern in the globe. Mercury is one of the heavy metals that cause multiple adverse effects to the living systems. In 2017, the World Health Organization (WHO) included it on its list of 10 substances of concern. It is one of the best confounding metals in the environment. Unlike many metals, it is not biologically active. Because of natural processes like mining, erosion, and volcanism, it is a scarce element in the Earth's crust. Although all mercury compounds are hazardous to people and animals, the most toxic forms are the organic ones, particularly methyl and dimethyl mercury. Due to anthropogenic activities and natural processes mercury is released into the atmosphere and due to its long half-life period, the rate of environmental breakdown is low. It exists in the form of element (Hg0) and divalent (Hg2) forms, based on the degree of oxidation in the environment. Due to its devastating toxic effects on organisms, it is currently recognised as one of the strongest neurotoxins. Due to its strong negative impact on the immune system, it is linked to persistent candidiasis growths, anaemia, memory loss, tremors, depression, tiredness, insomnia, headaches. Mercury is known to cause five categories of pathophysiological disorders i.e., immune system disorders, collagen diseases, neurological illnesses, cardiovascular diseases, and infections. This review provides an overview of the sources of mercury, the cumulative effects of mercury on different ecosystems, and phytoremediation for environmental restoration. It gives detailed information about the dangers of mercury exposure and its environmental sources, to make awareness about the mercury usage in different means of day to day life.
Keywords: Mercury, Methylation, Minamata disease, Alzheimer's disease
Halim MA, Majumder RK, Zaman MN. Paddy soil heavy metal contamination and uptake in rice plants from the adjacent area of Barapukuria coal mine, northwest Bangladesh. Arabian Journal of Geosciences. 2015;8(6):3391–3401. Available from: https://dx.doi.org/10.1007/s12517-014-1480-1
Lin YP, Cheng BY, Shyu GS, Chang TK. Combining a finite mixture distribution model with indicator kriging to delineate and map the spatial patterns of soil heavy metal pollution in Chunghua County, central Taiwan. Environmental Pollution. 2010;158(1):235–244. Available from: https://dx.doi.org/10.1016/j.envpol.2009.07.015
Vutukuru S. Acute Effects of Hexavalent Chromium on Survival, Oxygen Consumption, Hematological Parameters and Some Biochemical Profiles of the Indian Major Carp, Labeo rohita. International Journal of Environmental Research and Public Health. 2005;2(3):456–462. Available from: https://dx.doi.org/10.3390/ijerph2005030010
Mason RP, Morel FMM, Hemond HF. The role of microorganisms in elemental mercury formation in natural waters. Water, Air, & Soil Pollution. 1995;80(1-4):775–787. Available from: https://dx.doi.org/10.1007/bf01189729
Wittman D. How a war ends: A rational model approach. Journal of Conflict Resolution. 1979;23(4):743–763.
Yousafzai AM. Toxicological Effects of Industrial Effluents Dumped in River Kabul on Mahaseer, Tor Putitora at Aman Garh Industrial Area Nowshera, Peshawar, Pakistan. University of the Punjab thesis
Liu J, Zhang XH, Tran H, Wang DQ, Zhu YN. Heavy metal contamination and risk assessment in water, paddy soil, and rice around an electroplating plant. Environmental Science and Pollution Research. 2011;18(9):1623–1632. Available from: https://dx.doi.org/10.1007/s11356-011-0523-3
Tomiyasu T, Nagano A, Yonehara N, Sakamoto H, Rifardi, Ōki K, et al. Mercury contamination in the Yatsushiro Sea, south-western Japan: spatial variations of mercury in sediment. Science of The Total Environment. 2000;257(2-3):121–132. Available from: https://dx.doi.org/10.1016/s0048-9697(00)00502-7
Huang M, Deng S, Dong H, Dai W, Pang J, Wang X. Impacts of Atmospheric Mercury Deposition on Human Multimedia Exposure: Projection from Observations in the Pearl River Delta Region, South China. Environmental Science & Technology. 2016;50(19):10625–10634. Available from: https://dx.doi.org/10.1021/acs.est.6b00514
DoHaHSATSaDRUS. Toxicological profile for mercury. (pp. 1-100) United States. Department Of Health And Human Services. Agency For Toxic Substances And Disease Registry. 1989.
Pacyna EG, Pacyna JM, Sundseth K, Munthe J, Kindbom K, Wilson S, et al. Global emission of mercury to the atmosphere from anthropogenic sources in 2005 and projections to 2020. Atmospheric Environment. 2010;44(20):2487–2499. Available from: https://dx.doi.org/10.1016/j.atmosenv.2009.06.009
Sun G, Sommar J, Feng X, Lin CJ, Ge M, Wang W, et al. Mass-Dependent and -Independent Fractionation of Mercury Isotope during Gas-Phase Oxidation of Elemental Mercury Vapor by Atomic Cl and Br. Environmental Science & Technology. 2016;50(17):9232–9241. Available from: https://dx.doi.org/10.1021/acs.est.6b01668
Coetzee L, Preez HD, Vuren JV. Metal concentrations in Clarias gariepinus and Labeo umbratus from the Olifants and Klein Olifants River, Mpumalanga, South Africa: zinc, copper, manganese, lead, chromium, nickel, aluminium and iron. In: Water SA. (Vol. 28, pp. 433-448) Academy of Science of South Africa. 2002.
Kashyap AK, Steel J, Oner AF, Dillon MA, Swale RE, Wall KM, et al. Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proceedings of the National Academy of Sciences. 2008;105(16):5986–5991. Available from: https://dx.doi.org/10.1073/pnas.0801367105
Shakeri A, Moore F. The impact of an industrial complex on freshly deposited sediments, Chener Rahdar river case study, Shiraz, Iran. Environmental Monitoring and Assessment. 2010;169(1-4):321–334. Available from: https://dx.doi.org/10.1007/s10661-009-1173-5
Pirrone N, Cinnirella S, Feng X, Finkelman RB, Friedli HR, Leaner J, et al. Global mercury emissions to the atmosphere from anthropogenic and natural sources. Atmospheric Chemistry and Physics. 2010;10(13):5951–5964. Available from: https://dx.doi.org/10.5194/acp-10-5951-2010
Zhang L, Wang S, Wang L, Wu Y, Duan L, Wu Q, et al. Updated Emission Inventories for Speciated Atmospheric Mercury from Anthropogenic Sources in China. Environmental Science & Technology. 2015;49(5):3185–3194. Available from: https://dx.doi.org/10.1021/es504840m
Programme UNE. Global Mercury Assessment 2013: Sources, emissions, releases, and environmental transport. 2013.
RONCHETTI R, ZUURBIER M, JESENAK M, KOPPE JG, AHMED UF, CECCATELLI S, et al. Children's health and mercury exposure. Acta Paediatrica. 2006;95(s453):36–44. Available from: https://dx.doi.org/10.1080/08035250600886157
Bank MS. The mercury science-policy interface: History, evolution and progress of the Minamata Convention. Science of The Total Environment. 2020;722:137832. Available from: https://doi.org/10.1016/j.scitotenv.2020.137832
Al-Ansari EMAS, Abdel-Moati MAR, Yigiterhan O, Al-Maslamani I, Soliman Y, Rowe GT, et al. Mercury accumulation in Lethrinus nebulosus from the marine waters of the Qatar EEZ. Marine Pollution Bulletin. 2017;121(1-2):143–153. Available from: https://dx.doi.org/10.1016/j.marpolbul.2017.04.024
S G, B L, A L, F MA, P A, C C, et al. Drivers of variability in mercury and methylmercury bioaccumulation and biomagnification in temperate freshwater lakes. Chemosphere. 2021. Available from: https://pubmed.ncbi.nlm.nih.gov/33248739/
Su Y, Han FX, Chen J, Sridhar BBM, Monts DL. Phytoextraction and Accumulation of Mercury in Three Plant Species: Indian Mustard (<i>Brassica Juncea</i>), Beard Grass (<i>Polypogon monospeliensis</i>), and Chinese Brake Fern (<i>Pteris vittata)</i>. International Journal of Phytoremediation. 2008;10(6):547–560. Available from: https://dx.doi.org/10.1080/15226510802115091
Roberts HL. Some General Aspects of Mercury Chemistry. Advances in Inorganic Chemistry and Radiochemistry. 1968;11:309–339. Available from: https://doi.org/10.1016/S0065-2792(08)60169-7
Cotton FA, Wilkinson G. Advanced inorganic chemistry. (Vol. 594) New York. Wiley. 1962.
Rudnick RL, Gao S. Composition of the Continental Crust. In: G(DHaKKT., ed. Treatise on Geochemistry. (Vol. 3, pp. 1-64) Elsevier. 2003.
Alloway BJ. Heavy metals in soils: trace metals and metalloids in soils and their bioavailability. (Vol. 22) Springer. 2013.
Broussard LA, Hammett-Stabler CA, Winecker RE, Ropero-Miller JD. The Toxicology of Mercury. Laboratory Medicine. 2002;33(8):614–625. Available from: https://dx.doi.org/10.1309/5hy1-v3ne-2lfl-p9mt
E ND, F BM, P MT. The determination of mercury in whole blood and urine by inductively coupled plasma mass spectrometry. Spectrochimica Acta Part B: Atomic Spectroscopy. 1999;p. 1141–1153. Available from: https://doi.org/10.1016/S0584-8547(99)00057-9
Registry AUDoHaHSAfTSaD. Toxicological Profile for mercury. 1999.
Dart RC. Medical Toxicology. Lippincott Williams & Wilkins. 2004.
Bhan A, Sarkar NN. Mercury in the Environment: Effect on Health and Reproduction. Reviews on Environmental Health. 2005;20(1):39–56. Available from: https://dx.doi.org/10.1515/reveh.2005.20.1.39
Urano T, Naganuma A, Imura N. Methylmercury-cysteinylglycine constitutes the main form of methylmercury in rat bile. Research communications in chemical pathology and pharmacology. 1988;60(2):197–210. Available from: https://pubmed.ncbi.nlm.nih.gov/2899337/
Nartey VK, Klake RK, Doamekpor LK, Sarpong-Kumankomah S. Speciation of mercury in mine waste: case study of abandoned and active gold mine sites at the Bibiani–Anwiaso–Bekwai area of South Western Ghana. Environmental Monitoring and Assessment. 2012;184(12):7623–7634. Available from: https://dx.doi.org/10.1007/s10661-012-2523-2
Vannini A, Nicolardi V, Bargagli R, Loppi S. Estimating Atmospheric Mercury Concentrations with Lichens. Environmental Science & Technology. 2014;48:8754–8759. Available from: https://dx.doi.org/10.1021/es500866k
Nik MG, Shahbazi B, Grigoryan K. The study of mercury pollution distribution around a chlor-alkali petrochemical complex, Bandar Imam, southern Iran. Environmental Earth Sciences. 2012;67(5):1485–1492. Available from: https://dx.doi.org/10.1007/s12665-012-1592-4
Hutcheson MS, Smith CM, Rose J, Batdorf C, Pancorbo O, West CR, et al. Temporal and Spatial Trends in Freshwater Fish Tissue Mercury Concentrations Associated with Mercury Emissions Reductions. Environmental Science & Technology. 2014;48(4):2193–2202. Available from: https://dx.doi.org/10.1021/es404302m
Sinicropi MS, Amantea D, Caruso A, Saturnino C. Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning. Archives of Toxicology. 2010;84(7):501–520. Available from: https://dx.doi.org/10.1007/s00204-010-0544-6
Ipolyi I, Massanisso P, Sposato S, Fodor P, Morabito R. Concentration levels of total and methylmercury in mussel samples collected along the coasts of Sardinia Island (Italy) Analytica Chimica Acta. 2004;505(1):145–151. Available from: https://dx.doi.org/10.1016/s0003-2670(03)00174-0
Olivieri G, Novakovic M, Savaskan E, Meier F, Baysang G, Brockhaus M, et al. The effects of β-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and β-amyloid secretion. Neuroscience. 2002;113(4):849–855. Available from: https://dx.doi.org/10.1016/s0306-4522(02)00211-7
Uversky VN, Li J, Fink AL. Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein. Journal of Biological Chemistry. 2001;276(47):44284–44296. Available from: https://dx.doi.org/10.1074/jbc.m105343200
Diamond GL, Zalups RK. Understanding Renal Toxicity of Heavy Metals. Toxicologic Pathology. 1998;26(1):92–103. Available from: https://pubmed.ncbi.nlm.nih.gov/9502391/
Homma-Takeda S, Takenaka Y, Kumagai Y, Shimojo N. Selective induction of apoptosis of renal proximal tubular cells caused by inorganic mercury in vivo. Environmental Toxicology and Pharmacology. 1999;7(3):179–187. Available from: https://dx.doi.org/10.1016/s1382-6689(99)00012-5
Patrick L. Mercury toxicity and antioxidants: part i: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicitymercury toxicity. Toxicology and Applied Pharmacology. 2002;7(6):456–471. Available from: https://pubmed.ncbi.nlm.nih.gov/12495372/
Ji X, Liu C, Zhang M, Yin Y, Pan G. Mitigation of methylmercury production in eutrophic waters by interfacial oxygen nanobubbles. Water Research. 2020;173:115563. Available from: https://dx.doi.org/10.1016/j.watres.2020.115563
Jordan MP, Stewart AR, Eagles-Smith CA, Strecker AL. Nutrients mediate the effects of temperature on methylmercury concentrations in freshwater zooplankton. Science of The Total Environment. 2019;667:601–612. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.02.259
Satheeswaran T, Yuvaraj P, Damotharan P, Karthikeyan V, Jha DK, Dharani G, et al. Assessment of trace metal contamination in the marine sediment, seawater, and bivalves of Parangipettai, southeast coast of India. Marine Pollution Bulletin. 2019;149:110499. Available from: https://dx.doi.org/10.1016/j.marpolbul.2019.110499
Razavi NR, Qu M, Chen D, Zhong Y, Ren W, Wang Y, et al. Effect of eutrophication on mercury (Hg) dynamics in subtropical reservoirs from a high Hg deposition ecoregion. Limnology and Oceanography. 2015;60(2):386–401. Available from: https://dx.doi.org/10.1002/lno.10036
Quiroga-Flores R, Guédron S, Achá D. High methylmercury uptake by green algae in Lake Titicaca: Potential implications for remediation. Ecotoxicology and Environmental Safety. 2021;207:111256. Available from: https://dx.doi.org/10.1016/j.ecoenv.2020.111256
Liang P, Wu S, Zhang C, Zhang J, Wong M. Environmental geochemistry of Hg in intensive fish farming sites: Implications of Hg speciation change related to its health perspectives. Current Opinion in Environmental Science & Health. 2021;20:100242. Available from: https://dx.doi.org/10.1016/j.coesh.2021.100242
Liang P, Wu S, Zhang C, Xu J, Christie P, Zhang J, et al. The role of antibiotics in mercury methylation in marine sediments. Journal of Hazardous Materials. 2018;360:1–5. Available from: https://dx.doi.org/10.1016/j.jhazmat.2018.07.096
Rao MV. Mercury and its effects on mammalian systems- a critical review. Indian J Environ Toxicol. 1997;7:3–11. Available from: https://www.cabidigitallibrary.org/doi/full/10.5555/19982207395
Rao MV, Gangadharan B. Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro. Toxicology in Vitro. 2008;22(4):935–942. Available from: https://dx.doi.org/10.1016/j.tiv.2008.01.014
Endo T, Nakaya S, Kimura R, Murata T. Gastrointestinal absorption of inorganic mercuric compounds in vivo and in situ. Toxicology and Applied Pharmacology. 1984;74(2):223–229. Available from: https://dx.doi.org/10.1016/0041-008x(84)90146-7
Bulger RE. Renal Damage Caused by Heavy Metals. Toxicologic Pathology. 1986;14(1):58–65. Available from: https://pubmed.ncbi.nlm.nih.gov/3715331/
NAGANUMA A, FURUCHI T, MIURA N, HWANG GW, KUGE S. Investigation of Intracellular Factors Involved in Methylmercury Toxicity. The Tohoku Journal of Experimental Medicine. 2002;196(2):65–70. Available from: https://dx.doi.org/10.1620/tjem.196.65
Sahaphong S, Trump BF. Studies of cellular injury in isolated kidney tubules of the flounder. V. Effects of inhibiting sulfhydryl groups of plasma membrane with the organic mercurials PCMB (parachloromercuribenzoate) and PCMB (parachloromercuribenzenesulfonate) The American Journal of Pathology. 1971;63(2):277. Available from: https://pubmed.ncbi.nlm.nih.gov/5090641/
Endo T, Nakaya S, Kimura R. Gastrointestinal absorption of inorganic mercuric compounds in vitro. Toxicol. Appl. Pharmacol. 1986;83:187–196. Available from: https://www.sciencedirect.com/science/article/abs/pii/0041008X86902954
Cox C, Clarkson TW, Marsh DO, Amin-Zaki L, Tikriti S, Myers GG. Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis. Environmental Research. 1989;49(2):318–332. Available from: https://dx.doi.org/10.1016/s0013-9351(89)80075-1
Inouye M, Kajiwara Y. Strain difference of the mouse in manifestation of hydrocephalus following prenatal methylmercury exposure. Teratology. 1990;41(2):205–210. Available from: https://dx.doi.org/10.1002/tera.1420410212
Yeoh TS, Lee AS, Lee HS. Absorption of mercuric sulphide following oral administration in mice. Toxicology. 1986;41(1):107–111. Available from: https://dx.doi.org/10.1016/0300-483x(86)90108-3
Oudar P, Caillard L, Fillion G. In Vitro Effect of Organic and Inorganic Mercury on the Serotonergic System. Pharmacology & Toxicology. 1989;65(4):245–248. Available from: https://dx.doi.org/10.1111/j.1600-0773.1989.tb01166.x
Jonasson IR, Boyle RW. Geochemistry of mercury and origins of natural contamination of environment. Canadian Mining and Metallurgical Bulletin. 1972;65(717):32. Available from: https://www.osti.gov/etdeweb/biblio/6631686
Ullrich SM, Tanton TW, Abdrashitova SA. Mercury in the Aquatic Environment: A Review of Factors Affecting Methylation. Critical Reviews in Environmental Science and Technology. 2001;31(3):241–293. Available from: https://dx.doi.org/10.1080/20016491089226
Fitzgerald WF, Lamborg CH. Geochemistry of Mercury in the Environment. Treatise of Geochemistry. 2007;p. 1–47. Available from: https://doi.org/10.1016/B0-08-043751-6/09048-4
Clever HL, Johnson SA, Derrick ME. The Solubility of Mercury and Some Sparingly Soluble Mercury Salts in Water and Aqueous Electrolyte Solutions. Journal of Physical and Chemical Reference Data. 1985;14(3):631–680. Available from: https://dx.doi.org/10.1063/1.555732
Liu J, Feng X, Qiu G, Anderson CWN, Yao H. Prediction of Methyl Mercury Uptake by Rice Plants (Oryza sativa L.) Using the Diffusive Gradient in Thin Films Technique. Environmental Science & Technology. 2012;46(20):11013–11020. Available from: https://dx.doi.org/10.1021/es302187t
Keating MH, Beauregard D, Benjey WG, LD, WHMPE, Peters WD, et al. Mercury Study Report to Congress. An Inventory of Anthropogenic Mercury Emissions in the United States . (Vol. 2) EPA. 1997.
Li Y, Cai Y. Progress in the study of mercury methylation and demethylation in aquatic environments. Chinese Science Bulletin. 2013;58(2):177–185. Available from: https://dx.doi.org/10.1007/s11434-012-5416-4
Kerin EJ, Gilmour CC, Roden E, Suzuki MT, Coates JD, Mason RP. Mercury Methylation by Dissimilatory Iron-Reducing Bacteria. Applied and Environmental Microbiology. 2006;72(12):7919–7921. Available from: https://dx.doi.org/10.1128/aem.01602-06
Narita M, Huang CC, Koizumi T, Yamagata T, Endo G. Identification and characterization of anaerobic mercury-resistant bacteria isolated from mercury-polluted sediment. Water Science and Technology. 2000;42(3-4):109–114. Available from: https://dx.doi.org/10.2166/wst.2000.0366
Guimaraes JRD, Ikingura J, HA. Methyl mercury production and distribution in river water-sediment systems investigated through radiochemical techniques. Water, Air, and Soil Pollution. 2000;124(1- 2):113–124. Available from: https://link.springer.com/article/10.1023/A:1005206109083
Berlin I. PL., ed. Organic compounds of mercury. 1983.
Dutczak W, Clarkson TW, Ballatori N. Biliaryhepatic recycling of a xenobiotic: gallbladder absorption of methyl mercury. Am J Physiol . 1991. Available from: https://pubmed.ncbi.nlm.nih.gov/2058675/
Iavicoli I, Fontana L, Bergamaschi A. The Effects of Metals as Endocrine Disruptors. Journal of Toxicology and Environmental Health, Part B. 2009;12(3):206–223. Available from: https://dx.doi.org/10.1080/10937400902902062
Coccini T, Randine G, Candura SM, Nappi RE, Prockopld LD, Manzo L. Low-level exposure to methylmercury modifies muscarinic cholinergic receptorbinding characteristics in rat brain and lymphocytes:physiologic implication and new opportunities in biological monitoring. Pediatric Clinics of North America. 2000;54(2):29–33. Available from: https://pubmed.ncbi.nlm.nih.gov/10620521/
Wada H, Cristol DA, McNabb FMA, Hopkins WA. Suppressed Adrenocortical Responses and Thyroid Hormone Levels in Birds near a Mercury-Contaminated River. Environmental Science & Technology. 2009;43(15):6031–6038. Available from: https://dx.doi.org/10.1021/es803707f
McGregor AJ, Mason HJ. Occupational Mercury Vapour Exposure and Testicular, Pituitary and Thyroid Endocrine Function. Human & Experimental Toxicology. 1991;10(3):199–203. Available from: https://pubmed.ncbi.nlm.nih.gov/1678950/
Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, et al. Methylmercury Induces Pancreatic β-Cell Apoptosis and Dysfunction. Chemical Research in Toxicology. 2006;19(8):1080–1085. Available from: https://dx.doi.org/10.1021/tx0600705
Gonzalez-Ramirez D, Maiorino RM, Zuniga-Charles M, Xu Z, Hurlbut KM, Junco-Munoz P, et al. Sodium 2, 3-dimercaptopropane-1-sulfonate challenge test for mercury in humans: II. Urinary mercury, porphyrins and neurobehavioral changes of dental workers in Monterrey. Mexico. Journal of Pharmacology and Experimental Therapeutics. 1995;272(1):264–274. Available from: https://pubmed.ncbi.nlm.nih.gov/7815341/
Weiner JA, Nylander M. An estimation of the uptake of mercury from amalgam fillings based on urinary excretion of mercury in Swedish subjects. Science of The Total Environment. 1995;168(3):255–265. Available from: https://dx.doi.org/10.1016/0048-9697(95)04609-5
Magour S, Mäser H, Greim H. The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+K+‐ATPase after Partial Delipidisation with Lubrol®. Pharmacology & Toxicology. 1987;60(3):184–186. Available from: https://dx.doi.org/10.1111/j.1600-0773.1987.tb01730.x
Aschner M, Eberle NB, Miller K, Kimelberg HK. Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling. Brain Research. 1990;530(2):245–250. Available from: https://dx.doi.org/10.1016/0006-8993(90)91290-w
Cooper GP, Manalis RS. Influence of heavy metalson synaptic transmission: a review. 1983;4:69–83. Available from: https://pubmed.ncbi.nlm.nih.gov/6322059/
Coccini T, Randine G, Candura SM, Nappi RE, Prockop LD, Manzo L. Low-Level Exposure to Methylmercury Modifies Muscarinic Cholinergic Receptor Binding Characteristics in Rat Brain and Lymphocytes: Physiologic Implications and New Opportunities in Biologic Monitoring. Environmental Health Perspectives. 2000;108(1):29. Available from: https://dx.doi.org/10.2307/3454292
Atchison WD, Hare MF. Mechanisms of methylmercury‐induced neurotoxicity. The FASEB Journal. 1994;8(9):622–629. Available from: https://dx.doi.org/10.1096/fasebj.8.9.7516300
Chang LW. Neurotoxic effects of mercury—A review. Environmental Research. 1977;14(3):329–373. Available from: https://doi.org/10.1016/0013-9351(77)90044-5
Bapu C, Rao P, Sood PP. Restoration of methylmercury inhibited adenosine triphosphatases duringvitamin and monothiol therapy. J Environ PatholToxicol Oncol. 1998;17:75–80. Available from: https://pubmed.ncbi.nlm.nih.gov/9490323/
Aschner M, Aschner JL. Mercury neurotoxicity: Mechanisms of blood-brain barrier transport. Neuroscience & Biobehavioral Reviews. 1990;14(2):169–176. Available from: https://dx.doi.org/10.1016/s0149-7634(05)80217-9
Rajanna B, Hobson M, Harris L, Ware L, Chetty CS. Effects of cadmium and mercury on Na+, K+ATPases and the uptake of 3H-dopamine in rat brain synaptosomes. Arch Physiol Biochem. 1990;98:291–296. Available from: https://pubmed.ncbi.nlm.nih.gov/1708997/
M MK, I CE. Effects of mercury on lysosomal protein digestion in the kidney proximal tubule. a Journal of Technical Methods and Pathology. 1978;p. 165–174. Available from: https://pubmed.ncbi.nlm.nih.gov/203771/
Yasutake A, Hirayama K, Inouye M. Sex Difference in Acute Renal Dysfunction Induced by Methylmercury in Mice. Renal Failure. 1990;12(4):233–240. Available from: https://dx.doi.org/10.3109/08860229009060730
Miettinen M, Turpeinen O, Karvonen M, Elosuo R, Paavilainen E. Effect of diet on coronary-heart-disease mortality. The Lancet. 1973;302(7840):1266–1267. Available from: https://dx.doi.org/10.1016/s0140-6736(73)91009-x
Nabi S. Toxic Effects of Mercury. Springer India. 2014.
SJ W, DM V. Withrow and MacEwen’ssmall animal clinical oncology. (4). (pp. 73-74) St. Louis. Elsevier. 2007.
InSug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ. Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology. 1997;124(3):211–224. Available from: https://dx.doi.org/10.1016/s0300-483x(97)00153-4
Flora SJS, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian Journal of Medical Research. 2008;128(4):501. Available from: https://pubmed.ncbi.nlm.nih.gov/19106443/
Lund BO, Miller DM, Woods JS. Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochemical Pharmacology. 1993;45(10):2017–2024. Available from: https://dx.doi.org/10.1016/0006-2952(93)90012-l
Peraza MA, Ayala-Fierro F, Barber DS, Casarez E, Rael LT. Effects of micronutrients on metal toxicity. Environmental Health Perspectives. 1998;106(suppl 1):203–216. Available from: https://dx.doi.org/10.1289/ehp.98106s1203
Shenker BJ, Guo TL, Shapiro IM. Mercury-Induced Apoptosis in Human Lymphoid Cells: Evidence That the Apoptotic Pathway Is Mercurial Species Dependent. Environmental Research. 2000;84(2):89–99. Available from: https://dx.doi.org/10.1006/enrs.2000.4078
Smith PJ, Langolf GD, Goldberg J. Effect of occupational exposure to elemental mercury on short term memory. Occupational and Environmental Medicine. 1983;40(4):413–419. Available from: https://dx.doi.org/10.1136/oem.40.4.413
Ganther HE, Goudie C, Sunde ML, Kopecky MJ, Wagner P, Oh SH, et al. Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna. Science. 1972;175(4026):1122–1124. Available from: https://dx.doi.org/10.1126/science.175.4026.1122
Queiroz MLDS, Pena SC, Salles TSI, Capitani EMD, Saad STO. Abnormal antioxidant system in erythrocytes of mercury-exposed workers. Human & Experimental Toxicology. 1998;17(4):225–230. Available from: https://pubmed.ncbi.nlm.nih.gov/9617635/
Lash LH, Zalups RK. Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride. Journal of Biochemical Toxicology. 1996;11(1):1–9. Available from: https://dx.doi.org/10.1002/(sici)1522-7146(1996)11:1<1::aid-jbt1>3.0.co;2-o
Boujbiha MAM, Hamden K, Guermazi F, Bouslama A, Omezzine A, Feki AE. Impairment of Spermatogenesis in Rats by Mercuric Chloride: Involvement of Low 17β-Estradiol Level in Induction of Acute Oxidative Stress. Biological Trace Element Research. 2011;142(3):598–610. Available from: https://dx.doi.org/10.1007/s12011-010-8774-2
Rao MV. Histophysiological changes of sex organs in methylmercury intoxicated mice. Endocrinologia Experimentalis. 1989;23(1):55–62. Available from: https://pubmed.ncbi.nlm.nih.gov/2714228/
Rao MV. Mercury and its effects on mammalian systems- a critical review. Indian J Environ Toxicol. 1997;7:3–11. Available from: https://www.cabidigitallibrary.org/doi/full/10.5555/19982207395
Schrag SD, Dixon RL. Occupational Exposures Associated with Male Reproductive Dysfunction. Annual Review of Pharmacology and Toxicology. 1985;25(1):567–592. Available from: https://pubmed.ncbi.nlm.nih.gov/2408559/
Methylmercury NRC(CotTEo. Toxicological effects of methylmercury. .
Langworth S, Elinder C, Sundqvist KG. Minor effects of low exposure to inorganic mercury on the human immune system. Scandinavian Journal of Work, Environment & Health. 1993;19(6):405–413. Available from: https://dx.doi.org/10.5271/sjweh.1454
Bigazzi PE. Lessons from animal models: The scope of mercury-induced autoimmunity. Clinical Immunology and Immunopathology. 1992;65(2):81–84. Available from: https://dx.doi.org/10.1016/0090-1229(92)90210-f
Kolata G. New suspect in bacterial resistance:amalgam. The New York Times. 1993.
Norseth T, Clarkson TW. Intestinal transport of203Hg-labeled methylmercury chloride; role of biotransformation in rats. Arch Environ Health. 1971;22:258. Available from: https://pubmed.ncbi.nlm.nih.gov/5550173/
Donix M, Poettrich K, Weiss PH, Werner A, Kummer Rv, Fink GR, et al. Age-Dependent Differences in the Neural Mechanisms Supporting Long-Term Declarative Memories. Archives of Clinical Neuropsychology. 2010;25(5):383–395. Available from: https://dx.doi.org/10.1093/arclin/acq037
Dickson DW. Neuropathology of Alzheimer's disease and other dementias. Clinics in Geriatric Medicine. 2001;17(2):209–228. Available from: https://doi.org/10.1016/s0749-0690(05)70066-5
Sassin I, Schultz C, Thal DR, Rüb U, Arai K, Braak E, et al. Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathologica. 2000;100(3):259–269. Available from: https://dx.doi.org/10.1007/s004019900178
GL W. Neuropathologic changes in Alzheimer’sdisease. J Clin Psychiatry. 2003;p. 7–10. Available from: https://pubmed.ncbi.nlm.nih.gov/12934968/
Ariza ME, Bijur GN, Williams MV. Lead and mercury mutagenesis: Role of H2O2, superoxide dismutase, and xanthine oxidase. Environmental and Molecular Mutagenesis. 1998;31(4):352–361. Available from: https://doi.org/10.1002/(SICI)1098-2280(1998)31:4<352::AID-EM8>3.0.CO;2-K
T M, K F, L K, P L, E R, J. R, et al. Phytoremediation—biological cleaning of a polluted environment. Reviews on environmental health. 2004;19(1):63–82.
Xun Y, Feng L, Li Y, Dong H. Mercury accumulation plant Cyrtomium macrophyllum and its potential for phytoremediation of mercury polluted sites. Chemosphere. 2017;189:161–170. Available from: https://dx.doi.org/10.1016/j.chemosphere.2017.09.055
Wheeler M. Measuring mercury. Environmental Health Perspectives. 1996;104(8):826–830. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469443/
Rugh CL, Senecoff JF, Meagher RB, Merkle SA. Development of transgenic yellow poplar for mercury phytoremediation. Nature Biotechnology. 1998;16(10):925–928. Available from: https://dx.doi.org/10.1038/nbt1098-925
Salt DE, Blaylock M, Kumar NPBA, Dushenkov V, Ensley BD, Chet I, et al. Phytoremediation: A Novel Strategy for the Removal of Toxic Metals from the Environment Using Plants. Nature Biotechnology. 1995;13(5):468–474. Available from: https://dx.doi.org/10.1038/nbt0595-468
Patra M, Bhowmik N, Bandopadhyay B, Sharma A. Comparison of mercury, lead and arsenic with respect to genotoxic effects on plant systems and the development of genetic tolerance. Environmental and Experimental Botany. 2004;52(3):199–223. Available from: https://dx.doi.org/10.1016/j.envexpbot.2004.02.009
Millán R, Lominchar MA, Rodríguez-Alonso J, Schmid T, Sierra MJ. Riparian vegetation role in mercury uptake (Valdeazogues River, Almadén, Spain) Journal of Geochemical Exploration. 2014;140:104–110. Available from: https://dx.doi.org/10.1016/j.gexplo.2014.02.021
Cassina L, Tassi E, Pedron F, Petruzzelli G, Ambrosini P, Barbafieri M. Using a plant hormone and a thioligand to improve phytoremediation of Hg-contaminated soil from a petrochemical plant. Journal of Hazardous Materials. 2012;231-232:36–42. Available from: https://dx.doi.org/10.1016/j.jhazmat.2012.06.031
Hussein HS, Ruiz ON, Terry N, Daniell H. Phytoremediation of Mercury and Organomercurials in Chloroplast Transgenic Plants: Enhanced Root Uptake, Translocation to Shoots, and Volatilization. Environmental Science & Technology. 2007;41(24):8439–8446. Available from: https://dx.doi.org/10.1021/es070908q
Henriques B, Rocha LS, Lopes CB, Figueira P, Monteiro RJR, Duarte AC, et al. Study on bioaccumulation and biosorption of mercury by living marine macroalgae: Prospecting for a new remediation biotechnology applied to saline waters. Chemical Engineering Journal. 2015;281:759–770. Available from: https://dx.doi.org/10.1016/j.cej.2015.07.013
Zhang H, Wu S, Leibensperger EM. Source-receptor relationships for atmospheric mercury deposition in the context of global change. Atmospheric Environment. 2021;254:118349. Available from: https://dx.doi.org/10.1016/j.atmosenv.2021.118349
M P Sampada, M David. A Global Mercury Contamination and its Potential Hazards: A Review. Karnatak University Journal of Science 55(1), (2024), 1–16